As a diagnostic tool in the nanometer range, AFM has displayed a widespread diffusion in such a way that it is now quite unusual to read nanotechnology papers without seeing at least one AFM map. But now AFM and more generally SPM techniques start to represent a quite powerful and invaluable tool for fabrication of nano-objects and devices, with the unique opportunity of their evaluation and at least spatial characterization just after the realization. Techniques like DPN (Dip Pen Nanolithography ) in its different versions and modifications, or dynamic ploughing or local oxidation could have a brilliant and unique future both in nanoeletronics and in nanobiology fields.